Figure 4

Fenobam treatment increases the intermicturition interval. A-C. Representative urodynamic profile of WT mice before and after treatment. An intraperitoneal (IP) injection with fenobam significantly increased the IMI in 4/8 mice treated (B, E), while 4/8 mice stopped cycling (C). In the mice that stopped cycling, the mean time to resume bladder cycling and micturition after IP fenobam administration was 18.6 ± 5.0 minutes. The IMI was not significantly affected by IP DMSO (n = 7) (A, D). *P < 0.05 paired Student's t-test compared to baseline.