Figure 5From: Metabotropic glutamate receptor 5 (mGluR5) regulates bladder nociception UPEC Infection results in histological changes and bladder hyperalgesia. A. 24 hour infection with uropathogenic E. coli (UPEC) increases the VMR to bladder distention when compared to mock-infected (PBS) littermates. B. Infection with UPEC results in an increased infiltration of polymorphonuclear leukocytes (arrowheads), and a sloughing of the superficial facet cells. C. Distention alone does not result in the loss of superficial facet cells (arrows,). +/- SEM *p < 0.05, **p < 0.01, ***p < 0.001. Unpaired 2-way ANOVA with Bonferroni post-hoc test.Back to article page