Figure 2

Mechanically-activated currents are normal in Nav1.7/Nav1.8 DKO neurons. a) Three types of mechanically activated currents are evoked in cultures of DKO DRG neurons Left to right, examples of SA, RA and IA currents are depicted. The mechanical stimulation protocol is shown below each trace. b) The bar graph depicts percentage of each type of current kinetics observed in DKO and wild type littermates. The percentage of each type of MA currents in DKO neurons was similar to that of the WT littermates (Chi square test, p = 0.9268). c) The mean amplitude of peak SA/IA and RA currents measured at 8 μm were not significantly different between the DKO and wild type neurons (one way ANOVA, p = 0.8167).