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Figure 5 | Molecular Pain

Figure 5

From: Sodium channels and mammalian sensory mechanotransduction

Figure 5

Current-voltage relationship in cells that can generate all or none action potentials and those responding with small graded potentials. a, b) Representative current-voltage (I-V) relationships in WT cell responding to increasing step current injections by eliciting all-or-none action potentials (a) is depicted in b (arrows). Generation of an action potential is marked by the non-linearity in the relationship at the point where additional stimulation does not result in significantly increased potentials (arrow). b, c) examples of I-V relationship for wide and narrow action potentials from WT and DKO neurons. d, e) I-V relationship for a DKO cell eliciting graded responses to step current injections depicted in e (arrows). Note the linear I-V relationship (e, closed squares) where no significant overshoot is present (d). Holding the same cell at -90 mV results in appearance of an overshoot with non-linear I-V relationship (d, open squares). f)In a Nav1.7 KO cell responding with small graded potentials the I-V relationship is linear hence all-or-none action potentials are not generated compared to a Nav1.7KO cell capable of generating action potentials.

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