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Figure 2 | Molecular Pain

Figure 2

From: Warmth suppresses and desensitizes damage-sensing ion channel TRPA1

Figure 2

Warming reduces agonist-induced activity of TRPA1. A, example traces of currents evoked by formaldehyde (FA, 0.01%), menthol (MN, 250 μ M), flufenamic acid (FFA, 300 μ M) at 23°C (black) or 39°C (red). Superimposed traces were obtained from independent cells. Scale bar, 0.1 nA/pF, 30 s. B, normalized TRPA1 current densities at 23°C (white) and 39°C (black) induced by various agonists. *P < 0.05; **P < 0.001, n = 4-6 in each group. C, sample traces of currents evoked by 100 μ M MO (black bars) with or without pre-emptive heating as indicated. Scale bar, 0.2 nA/pF, 2 min. All data in panel A to C were obtained in rat TRPA1 except data for MN and FA in panel A and B that were obtained from human TRPA1.

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