Figure 6
From: Warmth suppresses and desensitizes damage-sensing ion channel TRPA1
Effects of warming on cold- and menthol-gated channel TRPM8. A, representative current traces induced by menthol (300 μ M, black bar) from a HEK293 cell transiently transfected with rat TRPM8. Letters a to d represent the time points for quantification shown in panel B. Ca2+ in the external solution was replaced with Ba2+. Scale bar, 0.5 nA/pF, 30 s; Vm = ± 80 mV. B, averaged current density at the indicated voltages. *P < 0.05 in Mann-Whitney rank-sum test; n = 4.