Effect of P2Y
R antagonist on nocifensive reflex in LNC-rats. Effect of daily successive administration (from day 0 to day 2) of MRS2395 or vehicle into TG on mean head-withdrawal reflex thresholds to mechanical (A) and heat (B) stimulation to the tongue in the LNC- or sham-rats on day 3 after operation. Head-withdrawal reflex threshold after LNC or sham operation with MRS2395 administration was compared with that before LNC or sham operation with MRS2395 administration. **: p < 0.01, ***: p < 0.001 (n = 6 in each group, Student's t-test).