Changes in 50% paw withdrawal threshold (PWT) to von Frey filaments and paw withdrawal latency (PWL) to radiant heat in rats with intra-tibial injections of MRMT-1 cells. (A): 50% PWT; (B): PWL. Note that implantation of MRMT-1 tumor cells into the tibial canal in rats produced significant decreases in 50% PWT and PWL in contrast to PBS or heat-killed cells injection. *p < 0.05, **p < 0.01, ***p < 0.001, as compared with PBS-implanted rats; #
p < 0.05, ##
p < 0.01, ###
p < 0.001, as compared with heat-killed (HK) cells-implanted rats, two-way ANOVA followed by Bonferroni post-hoc test.