Figure 8
From: Enhanced excitability of small dorsal root ganglion neurons in rats with bone cancer pain
Effects of intrathecal (i.t.) injection of tetrodotoxin (TTX) on pain behaviors and motor function in rats with intra-tibial injections of MRMT-1 cells. (A): 50% paw withdrawal threshold (PWT); (B): paw withdrawal latency (PWL); (C): inclined-plate test. Note that i.t. injection of TTX inhibited the tumor-evoked (as assessed by 50% PWT) and thermal hyperalgesia (as assessed by PWL), but did not affect the motor function in bone cancer rats. **p < 0.01, ***p < 0.001, as compared with i.t. injection of saline rats, two-way ANOVA followed by Bonferroni post-hoc test.