Figure 2

Effect of KN-93 on oxaliplatin-induced cold hyperalgesia in the acetone test. Rats were treated with oxaliplatin (4 mg/kg, i.p.) on days 1 and 2. We confirmed the incidence of cold hyperalgesia on day 5 and we carried out the drug evaluation on the same day. KN-93 (10-50 nmol) was administered intrathecally. The acetone test was performed immediately before (0 min) and at 30, 60, 90 and 120 min after administration. KN-93 had no effect on oxaliplatin-induced cold hyperalgesia. Values are expressed as the mean ± SEM. of 7-8 animals. **p < 0.01 compared with vehicle (Student's t-test).