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Figure 3 | Molecular Pain

Figure 3

From: PAPupuncture has localized and long-lasting antinociceptive effects in mouse models of acute and chronic pain

Figure 3

Local antinociceptive effects of PAP can be transiently boosted by injecting substrate or transiently blocked by interfering with A 1 R signaling. (A) hPAP (250 mU) followed one day later by substrate (200 nmol AMP) were injected into the popliteal fossa. (B) Data from the boxed area in (A) along with response following injection of AMP (200 nmol) alone into popliteal fossa. (C) hPAP (250 mU) was injected into the popliteal fossa followed two days later by CPX (1 mg/kg, i.p.). (D) Data from the boxed area in (C). (E) hPAP (250 mU) followed two days later by U73122 (5.4 nmol) were injected into the ipsilateral popliteal fossa. (F) Data from the boxed area in (E) along with response following injection of U73122 (5.4 nmol) alone into popliteal fossa. (A-F) Ipsi = ipsilateral hindpaw. Contra = contralateral hindpaw. Contralateral popliteal fossa was not injected. Wild-type (n = 10) and A 1 R−/− (n = 10) male mice in each cohort. Data are plotted as means ± s.e.m. Paired t-tests were used to compare responses at each time point to BL. *P < 0.05, **P < 0.005, ***P < 0.0005.

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