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Figure 4 | Molecular Pain

Figure 4

From: Retracted: Comparison of central versus peripheral delivery of pregabalin in neuropathic pain states

Figure 4

CaVα 2 δ-1 protein expression. CaVα2δ-1 protein expression was detected by immunohistochemistry at the dorsal horn regions of rats subjected to spinal nerve ligation or diabetes (A). Rats exposed to high dose (2.04 mg/kg/d) pregabalin provided intrathecally or intranasally had less expression of CaVα2δ-1 at the dorsal horn as compared to rats receiving near-nerve delivery of pregabalin or with saline delivery for both models of diabetic peripheral neuropathy (DPN) (B) and spinal nerve ligation (SNL) (C). As compared to control rat specimens, the presence of either spinal nerve ligation or diabetes uniformly led to upregulation of CaVα2δ-1 at the dorsal horn. Unmatched ANOVA tests were performed between cohorts receiving pregabalin and saline for each intervention and condition, and between intervention locations, with * indicating significant difference (p < 0.0125 after Bonferroni corrections) between cohorts [n = 3-5 specimens for each cohort].

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