Figure 3

A. In vivo patch clamp data: EPSC were recorded at the SG of the injured L5 segmental level. All SG neurons were recorded at a holding potential (V_H) of −70 mV, where no IPSC were observed. B. The average frequencies of EPSC in laminas I–II of the L5 segmental level: No significant difference in EPSC frequency was shown between groups A and B. The frequencies of EPSC in nerve injury group (C, D, E) were significantly increased compared with the sham group (*P < 0.001) and interestingly there were significant differences between groups C, D and E (**P < 0.001 and ***P < 0.05, respectively). C. The average amplitudes of EPSC in laminas I–II of the L5 segmental level: No significant difference in the mean amplitudes of EPSC was observed between groups A and B. There were significant differences in mean amplitudes of EPSC between the nerve injury groups (C, D, E) and the sham group (B) (*P < 0.05 and **P < 0.001, respectively) as well as significant differences between groups C, D and E (**P < 0.001).