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Table 2 Functional connectivity results in patients with FM and healthy controls

From: Patients with fibromyalgia display less functional connectivity in the brain’s pain inhibitory network

rACC seed: FM patients only (n = 28)
(MNI: x = 8, y = 46, z = 4)
Maximum voxel Cluster
size
Maximum
t-score
Cluster
p-value
rACC/Medial prefrontal cortex −8, 46, 4 16513 33.65 0.000**
Precuneus 6, −60, 26 2719 5.45 0.000**
Occipital cortex 44, −74, 32 611 4.78 0.000**
Occipital cortex −44, −72, 38 516 4.39 0.001**
rACC seed: Healthy controls only (n = 14)     
rACC/Medial prefrontal cortex −8, 46, 4 7122 22.69 0.000**
Posterior Cingulum/Precuneus 2, −40, 38 4180 6.40 0.000**
Parietal/Angular cortex −56, −60, 22 1020 5.62 0.000**
Parietal/Angular cortex 46, −70, 30 693 5.08 0.000**
rACC seed: FM patients > Healthy controls     
No significant regions     
rACC seed: Healthy controls > FM patients     
Amygdala/Parahippocampal −14, 0, −16 60 4.33 0.007*
Hippocampus −20, −24, -12 51 4.23 0.009*
Brainstem/PAG/Hippocampus 12, -24, -12 32 3.61 0.018*
Thalamus seed: FM patients only (n = 28)
(MNI: x = −14, y = −34, z = 12)
    
Thalamus 14, −34, 12 5523 30.91 0.000*
Thalamus seed: Healthy controls only (n = 14)     
Thalamus 14, −34, 12 989 21.81 0.000**
Orbitofrontal cortex −34, 50, −18 220 4.49 0.047**
Thalamus seed: FM patients > Healthy controls     
No significant regions     
Thalamus seed: Healthy controls > FM patients     
Orbitofrontal cortex −22, 54, −17 50 3.79 0.008*
  1. ** whole brain corrected for multiple comparisons * cluster corrected for multiple comparisons.
  2. Brain regions exhibiting significant functional connectivity with the seed regions rACC and thalamus, respectively, during calibrated pressure-evoked pain (n = 42). The seed regions, together with the PAG, amygdala, Nucleus Accumbens, hippocampus and prefrontal cortex, were considered regions of interest (ROI’s) and are marked in italics. The exact anatomical locations (x, y, z) are given in MNI coordinates. All results are corrected for multiple comparisons.