Compound | Dose mg/kg (route) | Max T bdecrease (°C) | P value * | Time post dosing (min) | Plasma concentration |
---|---|---|---|---|---|
AMG0635 | 3 (p.o.) | 0.47 | p < 0.05 | 120 | 0.38 ± 0.04 |
AMG8788 | 30 (p.o.) | 0.53 | p < 0.05 | 40 | 1.5 ± 0.6 |
AMG9678 | 10 (p.o.) | 0.72 | p < 0.001 | 60 | 0.04 ± 0.006 |
AMG9678 | 30 (p.o.) | 0.70 | p < 0.01 | 60 | 0.34 ± 0.1 |
AMG9678 | 100 (p.o.) | 0.83 | P < 0.05 | 60 | 0.36 ± 0.12 |
AMG2850 | 100 (p.o.) | 0.98 | p < 0.0001 | 140 | 22 ± 0.8 |
Compound 496 | 30 (p.o.) | 0.64 | p < 0.01 | 100 | 14.9 ± 0.95 |