Figure 3
Inflammation is associated with a significant decrease in BK Ca currents in cutaneous DRG neurons. A. Outward currents were evoked before (Total) and after the application of iberiotoxin (IbTx, 100 nM), with the voltage protocol shown below the Total current traces. The toxin sensitive current (the bottom set of current traces) was obtained by digitally subtracting current evoked in the presence of IbTx from that evoked prior to its application. B. Pooled current voltage (I-V) data from cutaneous neurons from naïve and inflamed (CFA) rats highlight the significant decrease in BKCa current density in neurons from inflamed rats. Note, pooled data are only from neurons in which BKCa current was detectable (> 200 pA at +60 mV). ** is p <0.01