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Figure 6 | Molecular Pain

Figure 6

From: Inflammation-induced changes in BKCa currents in cutaneous dorsal root ganglion neurons from the adult rat

Figure 6

Inflammation-induced changes in the pattern of BK Ca α-subunit splice variant and β subunit expression. A. Example of splice variants at the X4 site of the BKCa α subunit detected in mRNA harvested from single cutaneous DRG neurons. Each lane is the PCR product from a single neuron. The “zero insert” bottom band is dominant in all neurons. However, the larger inserts were more common in neurons from inflamed (CFA) than naïve rats. B. Pooled data for the expression of splice variants at the X4 site from 4 naïve and 4 inflamed rats were analyzed with a two-way ANOVA, which revealed a significant influence of inflammation (p < 0.05), but no interaction between inflammation and splice variant. C. Pooled data for β subunit expression from 4 naïve and 4 inflamed rats was also analyzed with a two-way ANOVA, which also revealed a significant influence of inflammation (p < 0.05), but no interaction between inflammation and subunit expression

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