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Table 3 Classification of RGS proteins

From: Molecular and cellular mechanisms of the age-dependency of opioid analgesia and tolerance

Subfamily Members Common features outside of RGS domain
RZ (or A) string GAIP/RGS19, RGSZ1/RGS20, RGSZ2/RGS17, Ret-RGS1 N-terminal cysteine
R4 (or B) RGS1, RGS2, RGS3, RGS4, RGS5, RGS8, RGS13, RGS16, RGS18 without specified domains or just an N-terminal amphipathic helix
R7 (or C) RGS6, RGS7, RGS9, RGS11 a GGL (G-like) domain and a DEP domain
R12 (or D) RGS10, RGS12, RGS14 may contain PDZ, PTB, or RBD domains
RA (or E) axin, conductin GSK binding, ß-catenin binding, PP2A homology, and dimerization domains
GEF (or F) p115-RhoGEF, PDZ-RhoGEF, LARG DH and PH domains
GRK (or G) GRK1, GRK2, GRK3, GRK4, GRK5, GRK6, GRK7 G-protein receptor kinase domain and PH domain