Table 3 Classification of RGS proteins
From: Molecular and cellular mechanisms of the age-dependency of opioid analgesia and tolerance
Subfamily | Members | Common features outside of RGS domain |
|---|---|---|
RZ (or A) string | GAIP/RGS19, RGSZ1/RGS20, RGSZ2/RGS17, Ret-RGS1 | N-terminal cysteine |
R4 (or B) | RGS1, RGS2, RGS3, RGS4, RGS5, RGS8, RGS13, RGS16, RGS18 | without specified domains or just an N-terminal amphipathic helix |
R7 (or C) | RGS6, RGS7, RGS9, RGS11 | a GGL (G-like) domain and a DEP domain |
R12 (or D) | RGS10, RGS12, RGS14 | may contain PDZ, PTB, or RBD domains |
RA (or E) | axin, conductin | GSK binding, ß-catenin binding, PP2A homology, and dimerization domains |
GEF (or F) | p115-RhoGEF, PDZ-RhoGEF, LARG | DH and PH domains |
GRK (or G) | GRK1, GRK2, GRK3, GRK4, GRK5, GRK6, GRK7 | G-protein receptor kinase domain and PH domain |