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Figure 8 | Molecular Pain

Figure 8

From: Role of JNK isoforms in the development of neuropathic pain following sciatic nerve transection in the mouse

Figure 8

Autotomy score. Autotomy was scored throughout the 30-day observation period. Autotomy is highest in wt mice injected with D-JNKI-1 once (), next highest in JNK2 KO mice (■) and then in wt mice (). Whilst regard to the time-course for onset of autotomy, JNK2 KOs (■) started to hurt their own ipsilateral hindpaws before wt injected with D-JNKI-1 once () and in wt(). This behavior was absent in both JNK1 () and JNK3 KO (▲), and in animals that received multiple D-JNKI-1 injections(♦). Autotomy scores are presented as mean + SEM.Significance:JNK1 KO, JNK3 KO and multiple D-JNKI-1 vs wt *p < 0.05; **p < 0.01; single D-JNKI-1 vs wt # p < 0.05; ## p < 0.01; ### p < 0.001, two-way ANOVA of repeated measures. n = same as in Figures 6 and 7.

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