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Figure 5 | Molecular Pain

Figure 5

From: Ethyl pyruvate attenuates formalin-induced inflammatory nociception by inhibiting neuronal ERK phosphorylation

Figure 5

Photomicrographs showing changes in CD11/b-IR in the spinal DH (L4-L5) 3 days after formalin injection. Inhibitory effects of EP on microglial activation were clear at 3 days following formalin injection. Insets are high magnification of the open rectangles. (A) Contralateral spinal DH of saline-pretreated and formalin-treated rats. (B) Ipsilateral spinal DH of saline-pretreated and formalin-treated rats. (C) Ipsilateral spinal DH of EP-pretreated and formalin-treated rats. Scale bar = 50 μm. (D) The Iba-1-IR intensity was measured as the average pixel intensity per 0.5 mm2 area within medial portion of the L4-L5 spinal DH at 3 days after formalin injection. The Iba-1-IR intensity was significantly increased by formalin injection, however this increased intensity significantly decreased by EP. Values are expressed as mean ± SEM. *P < 0.01 vs. normal rats (saline-pretreated and saline-treated) or control rats (saline-pretreated and formalin-treated).

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