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Figure 6 | Molecular Pain

Figure 6

From: Differential roles of galanin on mechanical and cooling responses at the primary afferent nociceptor

Figure 6

Differential role of galanin in CFA inflammation [A] CFA inflammation was confirmed through significant ipsilateral ankle joint swelling compared to the contralateral joint (***p < 0.001, paired t-test, n = 6). [B] Exogenous c.i.a. 100 μM galanin and c.i.a. 100 μM Gal2-11 both significantly facilitated mechano-nociceptor mechanical responses in CFA inflamed rats (** p < 0.01, *** p < 0.001, Kruskal-Wallis with Dunns multiple comparison test, n = 9). [C] Exogenous c.i.a. 100 μM galanin, but not c.i.a. 100 μM Gal2-11, reduced acetone evoked activity (* p < 0.05, one way ANOVA with post-hoc Bonferroni, n = 6).

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