Figure 1

Anti-hyperalgesic effect of eCT on pain behaviors in CCI rats. Mechanical hypersensitivity (a, c) and thermal hyperalgesia (b, d) developed over time on the ipsilateral hind paw in CCI rats. Elcatonin (20 U/kg), given subcutaneously five times a week starting 12 or 11 days after surgery, gradually improved mechanical hypersensitivity (a) or thermal hyperalgesia (b), respectively. Effects persisted for several days after cessation of the drug. The effects of eCT were dose-dependent on mechanical hypersensitivity (c) and thermal hyperalgesia (d) in CCI rats. 14 (a) or 12 (b, c, d) rats were used in each group. All RM-ANOVA revealed the significant differences (P < 0.01). Significant differences by Dunnett’s test or t-test: **P < 0.01, as compared to the sham-vehicle or the pre-operation; #P < 0.05, ##P < 0.01, as compared to the CCI-vehicle.