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Figure 5 | Molecular Pain

Figure 5

From: Anti-hyperalgesic effects of calcitonin on neuropathic pain interacting with its peripheral receptors

Figure 5

Verification of the site of action of eCT-induced anti-hyperalgesic effect as a sciatic CCI region. (a) Protocol of each experiment, including operation, behavioral test, eCT injection, and tissue collection. (b)(d) Reduction of eCT (20 U/kg, s.c.)-induced anti-hyperalgesic effect 4 days after operation (Experiment 1; (b) mechanical or (d) thermal hyperalgesia, n = 12). (c)(e) Anti-hyperalgesic effect of eCT (20 U/kg, s.c.) 15 days after operation (Experiment 2; (c) mechanical, n = 14 or (d) thermal hyperalgesia, n = 12). Each value represents the mean ± SEM. All ANOVA revealed the significant differences (P < 0.01). Significant differences by Dunnett’s test: **P < 0.01,*P < 0.05, as compared to the CCI-vehicle.

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