Figure 7

Influence of eCT on the CTR gene expression and the pain behavior under normal condition. (a) Reduction in CTR mRNA expression on intact sciatic nerve by 5 injections of eCT. (b)5 injections of eCT did not affect the pain behaviors under normal conditions before surgery, but prophylactic injections of eCT prevented the CCI-induced hypersensitivity. (a) Each value represents the mean of 6 data points from 12 animals ± SEM. Significant differences: *P < 0.05 by t-test. (b); Each value represents the mean ± SEM. RM-ANOVA showed the significant difference (P < 0.01). Significant differences by Dunnett’s test: **P < 0.01 or ##P < 0.01, as compared to the sham-vehicle or CCI-vehicle, respectively.