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Figure 4 | Molecular Pain

Figure 4

From: Contribution of microglia and astrocytes to the central sensitization, inflammatory and neuropathic pain in the juvenile rat

Figure 4

Effect of microglial inhibitor, P2X receptor antagonists and p38 MAPK inhibitor on neuronal excitation. Effect of the microglial inhibitor minocycline (20 μM) (A), the specific P2X1,2,3,5 antagonist pyridoxal-phosphate-6-azophenyl-2',4'-disulfonate (PPADS, 20 μM) (B), the specific P2X1,2,3,4 antagonist 2',3'-O-(2,4,6-trinitrophenyl) adenosine 5'-triphosphate (TNP-ATP, 1 μM) (C) and the p38 MAPK inhibitor SB203580 (1 μM) (D) on neuronal excitation in control rats, rats injected with complete Freund adjuvant (CFA), and rats subjected to peripheral nerve injury (PNI). Data are expressed as % inhibition of the mean intensity of the optical response during the preincubation period. *P < 0.05, **P < 0.01.

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Molecular Pain

ISSN: 1744-8069

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