Figure 2

LPS but not intraplantar capsaicin results in significant changes in spinal tight junction protein occludin. Intrathecal LPS injection (A) but not intraplantar capsaicin (B) induces disturbed occludin morphology in lumbar spinal cord. Number of intact vessels are significantly decreased in ipsilateral dorsal, ipsilateral ventral, contralateral dorsal, and contralateral ventral spinal cord quadrants after intrathecal LPS, but not at various timepoints after capsaicin in either male (C) or female (D) rats. Abbreviations: intrathecal (IT), lipopolysaccharide (LPS), von Willebrand Factor (VWF), occludin (OCC) ipsilateral dorsal (ID), ipsilateral ventral (IV), contralateral dorsal (CD), contralateral ventral (CV), others as in Figure 1.