Intraplantar carrageenan does not result in significant reduction in lumbar spinal occludin protein. Intraplantar carrageenan does not result in the reduction of spinal occludin protein at 72 hours post-carrageenan in male and female rats as compared to vehicle, but this is detected after intrathecal LPS. (A). Densitometric quantification reveals significant decreases in the occludin/actin ratio after LPS, but not at 72 hours post-carrageenan as compared to vehicle (B). Abbreviations: female (FEM), others as in Figure 1, 2, and 3.