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Figure 3 | Molecular Pain

Figure 3

From: Milnacipran inhibits glutamatergic N-Methyl-D-Aspartate receptor activity in Spinal Dorsal Horn Neurons

Figure 3

(A) Milnacipran does not inhibit AMPA receptor-mediated responses in dorsal horn neurons. Milnacipran did not inhibit AMPA-induced currents. (B) Representative traces of dorsal root stimulation evoked monosynaptic NMDA- and AMPA-mediated EPSCs. NMDA-mediated EPSCs were recorded at +40 mV. AMPA-mediated EPSCs were recorded at −70 mV. Milnacipran reversibly decreased the amplitudes of NMDA-, but not AMPA-mediated EPSCs. (C) Comparison of the NMDA- and AMPA-mediated EPSCs in control and in the presence of milnacipran. * P < 0.01.

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Molecular Pain

ISSN: 1744-8069

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