Figure 5

Transient amplitude does not influence PMCA function. The recovery of [Ca²⁺]_c from transients induced by application of high K⁺ solution (50 mM for 0.3 s) in thapsigargin-treated neurons was measured by recovery rate constant (τ) in control neurons (A) and neurons from the 4^th lumbar (L4, B) and L5 dorsal root ganglia (C) after spinal nerve ligation (SNL). In each, transient amplitude did not influence τ (regression P of 0.16, 0.36, and 0.43 respectively). The best-fit trend line and coefficient of determination (R²) are shown.