Figure 6
From: Painful nerve injury increases plasma membrane Ca2+-ATPase activity in axotomized sensory neurons
Influence of neuronal activity on PMCA function. The rate constant (τ) for recovery was determined for transients induced at 2 min intervals by application of high K+ solution (50 mM for 0.3 s) in thapsigargin-treated neurons (n = 6). Repeated activation caused progressive acceleration of the recovery in control neurons (A) and neurons from the fourth lumbar dorsal root ganglia after spinal nerve ligation (SNL L4) (B), but not after axotomy in SNL L5 neurons (C). Mean ± SD; * P < 0.05 by repeated measures ANOVA with Dunnett’s post hoc test.