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Figure 2 | Molecular Pain

Figure 2

From: Activation of extracellular signal-regulated protein kinase 5 is essential for cystitis- and nerve growth factor-induced calcitonin gene-related peptide expression in sensory neurons

Figure 2

NGF immuno-neutralization attenuated cystitis-induced CGRP expression in L6 DRG. The number of CGRP immunoreactive neurons was significantly higher in L6 DRG from animals treated with CYP and control IgG (A, C) when compared to those from animals treated with NGF neutralizing antibody and CYP (B, C). Blockade of NGF activity in cystitis animals also reduced CGRP transcription in the L6 DRG (D). *, p < 0.05 vs CYP + IgG. n = 5 animals for each group. Bar = 60 μm.

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