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Figure 5 | Molecular Pain

Figure 5

From: Activation of extracellular signal-regulated protein kinase 5 is essential for cystitis- and nerve growth factor-induced calcitonin gene-related peptide expression in sensory neurons

Figure 5

Co-localization of CGRP with phospho-CREB in bladder afferent neurons during cystitis. Double immunostaining showed that CGRP cells (A, green cells indicated by yellow arrows) often expressed phospho (p)-CREB (B, red nuclear staining, C was the merged photomicrograph of A and B indicating co-localization of CGRP and p-CREB: yellow arrows) during cystitis. In FB-labeled bladder afferent neurons (D, blue cells indicated by yellow arrows), CGRP (E, green cells) was also co-expressed with p-CREB (F: red nuclear staining; G was the merged photomicrograph of D, E and F indicating bladder afferent neurons expressing both CGRP and p-CREB indicated by yellow arrows). White arrows indicated CGRP neurons that did not have p-CREB. Bar = 60 μm.

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Molecular Pain

ISSN: 1744-8069

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