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Figure 7 | Molecular Pain

Figure 7

From: Activation of extracellular signal-regulated protein kinase 5 is essential for cystitis- and nerve growth factor-induced calcitonin gene-related peptide expression in sensory neurons

Figure 7

NGF immuno-neutralization reduced the level of CREB phosphorylation in CGRP neurons during cystitis and reversed cystitis-induced bladder overactivity. The number of phospho (p)-CREB immunoreactive neurons was significantly higher in L6 DRG from animals treated with CYP and control IgG (A, C) when compared to those from animals treated with NGF neutralizing antibody and CYP (B, C). NGF neutralization also reduced cystitis-induced increases in the number of L6 DRG neurons co-expressing CGRP and p-CREB (D), and reversed cystitis-induced increases in micturition frequency (E). *, p < 0.05 vs CYP + IgG. #, p < 0.05 vs vehicle treatment. n = 4 animals for each group. Bar = 40 μm.

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