Minocycline administration prevents development of mechanical allodynia after peripheral nerve injury. Mechanical sensitivity was assessed by the von Frey test before, and 1, 3, 7, 13, 15, and 16 days after nerve injury. The 50% response threshold of the injured left hindpaw decreased to 3.86 ± 0.34 by 72 hours (squares). The response threshold of rats receiving daily intraperitoneal injections of minocycline did not change (4.90 ± 0.08, triangles) and was similar to the threshold of the uninjured rats (4.85 ± 0.16, triangles, red line). Minocycline administration was stopped after seven days; one week later, all injured rats demonstrated the same threshold. Averages and standard deviations of data collected from 3 – 6 animals at each time point are presented.