Suppression of ERK and mTOR signaling by resveratrol is time dependent. TG neurons were treated with 100 μM resveratrol for 0, 10, 30, and 100 min. Resveratrol induces an increase in phosphorylation of AMPK (A) maximally with 10 and 30 min treatment. Resveratrol decreases the phosphorylation of ERK (B), eIF4E (C), AKT (D), mTOR (E), TSC2 (F) 4EBP (G) and rS6 (I) and this effect is time-dependent. Resveratrol increased eIF4G phosphorylation (H).