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Figure 7 | Molecular Pain

Figure 7

From: Resveratrol engages AMPK to attenuate ERK and mTOR signaling in sensory neurons and inhibits incision-induced acute and chronic pain

Figure 7

Local resveratrol blocks plantar incision-induced allodynia in a dose-related manner. Animals received a plantar incision on the left hindpaw. Resveratrol (1 μg or 10 μg) or vehicle was injected into the paw around the incision either immediately following incision and 1 day post incision (A, B) or 1 and 3 days following incision (C). A) Resveratrol injection (1 μg or 10 μg) immediately following incision and 1 day post incision significantly blocked plantar incision induced allodynia in a dose-dependent manner. B) Area under the curve (AUC) analysis showing dose-related effects in A. C) Resveratrol injection (10 μg) on day 1 and 3 following incision significantly blocks plantar incision induced allodynia. Red arrows show times of resveratrol injection.

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Molecular Pain

ISSN: 1744-8069

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