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Figure 8 | Molecular Pain

Figure 8

From: Resveratrol engages AMPK to attenuate ERK and mTOR signaling in sensory neurons and inhibits incision-induced acute and chronic pain

Figure 8

Resveratrol blocks IL-6- and plantar incision-induced persistent sensitization. A) Intraplantar injection of IL-6 (0.1 ng) with resveratrol (10 μg) co-treatment on Day 1 abolished the IL-6 induced persistent sensitization precipitated by PGE2 injection on day 6. B) Intraplantar injection of resveratrol (10 μg) at the time of incision and 1 day post incision abolished plantar incision-induced persistent sensitization precipitated by PGE2 injection on day 14 after incision. C) Intraplantar injection of resveratrol (10 μg) on day 1 and 3 post incision abolished plantar incision induced persistent sensitization precipitated by PGE2 injection on day 14 after incision.

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Molecular Pain

ISSN: 1744-8069

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