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Figure 1 | Molecular Pain

Figure 1

From: Dose-dependent expression of neuronal injury markers during experimental osteoarthritis induced by monoiodoacetate in the rat

Figure 1

Histopathology of knee sections of OA animals. Rats received an intra-articular injection of 0.3 (A-E), 1 (F-J) or 2 mg (K-O) of MIA and were sacrificed at 3 (A, F, K), 7 (B, G, L), 14 (C, H, M), 21 (D, I, N) and 31 days (E, J, O) post-MIA injection. Each rat knee image is representative of a group of 5 animals. The sections were stained with Safranin-O that stained cartilage and its proteoglycan content and Fast Green, which stains bone. Histopathological alterations, namely decrease in proteoglycan staining, chondrocyte death, loss of intercellular matrix, decrease of the thickness of the articular cartilage, erosion of the hyaline articular cartilage and exposure of the subcondral bone, were dose and time-dependent. C indicates cartilage; SB, subchondral bone; M, meniscus. Scale bar: 200 μm.

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