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Figure 5 | Molecular Pain

Figure 5

From: The majority of dorsal spinal cord gastrin releasing peptide is synthesized locally whereas neuromedin B is highly expressed in pain- and itch-sensing somatosensory neurons

Figure 5

Nmb is expressed in small and large diameter DRG neurons. (A-D) FISH for Nmb (red) and immunostaining for peripherin (green), an intermediate filament that is present in small diameter DRG neurons. Histogram shows the percentage of Nmb+ neurons that express peripherin (red bar) and the percentage of Peripherin+ neurons that express Nmb (green bar). Mean ± SEM. (E-H) FISH for Nmb (red) and immunostaining for NF200 (green), a marker of large diameter myelinated neurons, and quantification of overlapping expression. Scale bar = 50 μm (I) Distribution of soma sizes of Nmb+, Peripherin+, and NF200+ DRG neurons, in 100 μm2 bins.

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Molecular Pain

ISSN: 1744-8069

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