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Figure 6 | Molecular Pain

Figure 6

From: The majority of dorsal spinal cord gastrin releasing peptide is synthesized locally whereas neuromedin B is highly expressed in pain- and itch-sensing somatosensory neurons

Figure 6

Nmb is expressed in peptidergic and nonpeptidergic nociceptors. (A-D) FISH for Nmb (red) and Ret (green), a marker for small diameter nonpeptidergic nociceptors and RA mechanoreceptors. Arrow indicates a large diameter, Ret+ neuron, all of which are Nmb-. (E-H) FISH for Nmb (red) and TrkA (green), a marker for peptidergic nociceptors. (I-M) FISH for Nmb (red) and Ret (green), combined with immunostaining for TrkA (blue). Quantification shows the percentages of Nmb+ neurons which also express Ret or TrkA (green), or which express neither marker (red). (N-Q) FISH for Nmb (red) and binding of IB4 (green). (R-U) FISH for Nmb (red) combined with immunostaining for Pap (green). (V-Y) FISH for Nmb (red) and MrgprD (green). Scale bar = 50 μm.

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Molecular Pain

ISSN: 1744-8069

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