Figure 5
AMPA and kainate receptor-mediated excitatory postsynaptic currents in LI neurons of the adult ACC. A), Diagram showing the placement of stimulating and recording electrode in the ACC. B), The control represented evoked EPSCs recorded under the blocking of GABAA and NMDA receptors activities with bath application of PTX (100 μM) and D-2-amino-5-phosphono-pentanoic acid (D-AP5, 50 μM). After application of SYM 2206 (100 μM), the residual currents were totally blocked by CNQX (25 μM). Each trace represented an average of 5–10 consecutive recording. C), Example showing the time course of SYM 2206 and CNQX effects on the neuron showed in B. D), The statistic data showing the percentage of SYM 2206 resistant-CNQX sensitive currents. E), Scaled traces showed the different kinetics of SYM 2206 sensitive and resistant currents. F), Pool data showing the rise time of SYM 2206 sensitive and resistant currents were similar. G), Summarized data showing the decay time of SYM 2206 sensitive and resistant currents were different. “*” indicate P < 0.05.