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Figure 3 | Molecular Pain

Figure 3

From: Acute cold hypersensitivity characteristically induced by oxaliplatin is caused by the enhanced responsiveness of TRPA1 in mice

Figure 3

TRPA1 is involved in oxaliplatin-induced acute cold hypersensitivity. ( A) Mice were intraperitoneally administered vehicle or oxaliplatin (5 mg/kg) 2 h before the cold-plate test, with vehicle or HC-030031 (100 mg/kg) intraperitoneally injected 30 min before testing. n = 6. ( B) TRPA1+/+ or TRPA1−/− mice were intraperitoneally administered vehicle or oxaliplatin (5 mg/kg) 2 h before the cold-plate test. n = 7–8. Escape behaviors in response to cold stimulation (5°C) were scored in a cold-plate test. Data are presented as the mean ± S.E.M. ** p < 0.01, *** p < 0.001.

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Molecular Pain

ISSN: 1744-8069

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