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Figure 6 | Molecular Pain

Figure 6

From: Identification of 5-HT receptor subtypes enhancing inhibitory transmission in the rat spinal dorsal horn in vitro

Figure 6

Effects of 5-HT 2C receptor agonist and antagonist on sIPSCs. (A) Sample trace of sIPSCs recorded before, during and after the application of WAY 161503 (30 μM). Lower traces show sIPSCs before (left) and after (right) the application of WAY 161503 in the expanded time scale. (B) In the same (A) neuron, sample trace of sIPSCs recorded before (N-desmethylciozapine 10 μM), during and after the application of WAY 161503 in the presence of N-desmethylciozapine. Lower traces show sIPSCs before (left) and after (right) the application of N-desmethylciozapine. The bar graph shows the relative frequency (C) and amplitude (D) for WAY 161503, N-desmethylciozapine and WAY 161503 + N-desmethylciozapine, respectively (paired t-test, ** P < 0.01, n = 7).

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Molecular Pain

ISSN: 1744-8069

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