Histograms showing the temperature withdrawal thresholds of the affected hindpaw glabrous skin as determined by the hot and cold plate test. The SNI group shows a significantly lower paw withdrawal threshold at 50 and 43°C after 5 and 10 weeks postoperatively as compared to the sham group. Also at 14 and 5°C the SNI group has a significantly lower withdrawal threshold as compared to the Sham group only at 5 and 10 weeks. N = 9 per group. One-way ANOVA with post-hoc Turkey test, unpaired t-test *: P < 0.05, **: P < 0.01, ***:P < 0.001.