Two-dimensional density profile of epidermal CGRP-IR fibers in the distal and proximal parts of the foot sole. Note patches with lower CGRP-IR density in the sham group, which represent the footpads. After 2 weeks PO there is a complete abolishment of CGRP-IR fibers in the center area (tibial). Five weeks PO an enhanced density of epidermal CGRP-IR fibers within the medial and lateral areas can be observed. Ten weeks PO the epidermal CGRP-IR fiber density profile shows re-innervation of fibers into the previously denervated center area (tibial). Note that the lower density in the footpads that is seen in the sham group is not observed at 10 weeks PO in the SNI group.