Skip to main content

Table 3 Significant differences in pain-, neurotrophin-, nerve-, and disc-related genes in more degenerated discs (Grades iv and v) compared to less degenerated discs (Grades i – iii)

From: Genome-wide analysis of pain-, nerve- and neurotrophin -related gene expression in the degenerating human annulus

Gene name Gene identifier Fold change Direction p-value
A. Pain-, Neurotrophin- and Nerve-related Genes
Adrenergic, beta, receptor kinase 2 AI478542 1.16 Up 0.045
Ataxin 10 AF119662 2.62 Up 0.008
Bradykinin receptor B1 NM_000710 1.09 Up 0.023
Calcitonin gene related peptide AI478743 1.51 Up 0.035
Catechol-O-methyltransferase NM_001670 1.17 Up 0.020
Cholinergic receptor, muscarinic 1 AI500293 1.60 Down 0.042
Clusterin M25915 12.76 Up 0.010
EGF, latrophilin and seven transmembrane domain containing 1 NM_022159 1.74 Up 0.040
Endoplasmic reticulum aminopeptidase 2 BE889628 1.28 Up 0.036
Endoplasmic reticulum protein 44 BC005374 2.08 Up 0.043
GABA binding protein 2 BC002557 4.54 Down 0.027
GABA(A) receptor-associated protein NM_007278 3.78 Up 0.049
Gap junction protein, alpha 1, 43 kDa NM_000165 4.91 Up 0.017
Glutathione peroxidase 1 NM_000581 3.42 Up 0.036
Glutamate receptor, metabotropic 1 U31216 1.06 Up 0.0082
Guanine nucleotide binding protein (G protein), gamma 10 NM_004125 2.97 Up 0.049
Guanine nucleotide binding protein (G protein) alpha inhibiting activity polypeptide 3 J03198 3.22 Up 0.021
Guanine nucleotide binding protein (G protein) beta polypeptide 1 NM_002074 4.04 Up 0.015
Heat shock protein 90 kDa alpha (cytosolic), blass B member 1 AF275719 2.96 Up 0.038
Hydroxysteroid (17-beta) dehydrogenase 4 NM_000414 1.88 Up 0.049
Kv channel interacting protein 2 AF367019 1.52 Up 0.027
Neurogenin 2 AF022859 1.08 up 0.045
Neuron navigator 1 N57538 2.42 Up 0.009
Neuron navigator 2 AA011020 1.11 Up 0.043
Neuropilin 2 AA295257 1.87 Up 0.037
Neuroplastin NM_017455 2.78 Up 0.048
Opioid growth factor receptor AF172449 1.31 Up 0.008
Palmitoyl-protein thioesterase 1 NM_000310 3.04 Up 0.019
PDZ and LIM domain 5 AV715767 5.1 Up 0.006
Peroxisome proliferator-activated receptor delta NM_006238 3.31 Down 0.031
Phytanoyl-CoA 2-hydroxylase NM_006214 2.17 Up 0.049
Potassium channel tetramerisation domain containing 10 AS073741 2.69 Up 0.036
Potassium channel tetramerisation domain containing 15 W73820 1.33 Up 0.013
Potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3 NM_002252 1.66 Up 0.031
Presenilin 1 NM_007318 1.61 Up 0.024
Regulator of G-protein signaling 5 AF159570 2.31 Up 0.047
Reticulon 4 (Neurite growth inhibitor) AF20999 4.61 Up 0.001
Solute carrier family 38, member 1 NM_030674 2.13 Up 0.039
Solute carrier family 7 (catonic amino acid transporter, y + system), member 1 AA148507 1.44 Up 0.017
Somatostatin receptor 4 NM_001052 1.09 Down 0.033
S100 calcium binding protein A4 NM_002961 7.44 Up 0.010
Thioredoxin domain containing 12 (endoplasmic reticulum) AF131758 2/42 Up 0.009
Thy-1 cell surface antigen AL161958 3.48 Up 0.006
B. Proinflammatory cytokine and chemokine genes:
Chemokine (C-X-C motif) receptor 7 AI817041 3.32 Up 0.043
Chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1) NM_000609 1.90 Up 0.024
FGF receptor 2 T83672 1,12 Up 0.020
IL-17A NM_002190 1.05 Up 0.048
Interferon induced transmembrane protein 1 (9–27) NM_003641 2.72 Up 0.026
PDGF C NM_016205 3.07 Up 0.041
PDGF alpha polypeptide NM_006206 5.73 Up 0.021
PDGF receptor, beta polypeptide NM_003609 2.10 Up 0.033
PDGF receptor-like NM_006207 1.82 Up 0.037
TGF beta NM_000358 6.68 Up 0.035
Latent TGF beta binding protein 1 NM_000627 3.29 Up 0.016
TNF receptor-associated factor 5 NM_004619 1.34 Up 0.014
VEGF B NM_003377 1.09 Up 0.037
C. Genes with special disc relevance:
ADAM metallopeptidase domain 17 NM_003183 1.56 Up 0.001
Apoptosis-inducing factor, mitochondrion associated, 1 NM_004208 1.42 Up 0.019
BMP receptor, type II (serine/threonine kinase) AI457436 1.51 Up 0.027
Calcitonin receptor-like AI1478743 1.51 Up 0.035
Caspase 2, apoptosis-related cysteine peptidase AU153405 1.63 Up 0.028
Caspase 6, apoptosis-related cysteine peptidase BC000305 1.63 Up 0.048
Collagen, type I, alpha 1 K01228 2.69 Up 0.046
Collagen, type I, alpha 2 NM_000089 13.27 Up 0.007
Collagen type III, alpha 1 AU144167 10.3 Up 0.036
Collagen type IV, alpha 2 X05610 2.02 Up 0.021
Collagen type V, alpha 1 AI9833428 1.5 Up 0.039
Collagen type VI, alpha 3 NM_004369 5.85 Up 0.036
Connective tissue growth factor M92934 6.47 Up 0.009
EGF-containing fibulin-like extracellular matrix protein 1 NM_004105 1.49 Up 0.005
Fibronectin 1 AK026737 16.82 Up 0.017
Fibronectin leucine rich transmembrane protein 2 NM_013231 2.78 Up 0.023
Hypoxia inducible factor 1, alpha subunit NM_001530 3.61 Up 0.037
Janus kinase 2 AF001362 1.3 Up 0.002
Laminen, alpha 5 BC003355 1.39 Up 0.042
Laminin, beta 1 NM_002291 2.13 Up 0.045
Lumican NM_002345 17.58 Up 0.015
Mitogen-activated protein kinase 1 AF320999 4.61 Up 0.0017
Mitogen-activated protein kinase 13 BC000433 1.37 Up 0.014
Mitogen-activated protein kinase kinase kinase 3 BF971923 1.67 Up 0.045
Nitric oxide synthase 3 NM_000603 4.77 Down 0.030
SPARC (osteonectin), cwcv and Kazal-like domains proteoglycan (testican) 1 AF231124 2.74 Up 0.027
Thrombospondin 1 BF055462 1.20 Up 0.033
TIMP metallopeptidase inhibitor 2 BF107565 3.57 Up 0.034
TIMP metallopeptidase inhibitor 3 U67195 2.88 Up 0.035
Vimentin AI520969 1.35 Up 0.031