Gene name | Gene identifier | Fold change | Direction | p-value |
---|---|---|---|---|
A. Pain-, Neurotrophin- and Nerve-related Genes | ||||
Adrenergic, beta, receptor kinase 2 | AI478542 | 1.16 | Up | 0.045 |
Ataxin 10 | AF119662 | 2.62 | Up | 0.008 |
Bradykinin receptor B1 | NM_000710 | 1.09 | Up | 0.023 |
Calcitonin gene related peptide | AI478743 | 1.51 | Up | 0.035 |
Catechol-O-methyltransferase | NM_001670 | 1.17 | Up | 0.020 |
Cholinergic receptor, muscarinic 1 | AI500293 | 1.60 | Down | 0.042 |
Clusterin | M25915 | 12.76 | Up | 0.010 |
EGF, latrophilin and seven transmembrane domain containing 1 | NM_022159 | 1.74 | Up | 0.040 |
Endoplasmic reticulum aminopeptidase 2 | BE889628 | 1.28 | Up | 0.036 |
Endoplasmic reticulum protein 44 | BC005374 | 2.08 | Up | 0.043 |
GABA binding protein 2 | BC002557 | 4.54 | Down | 0.027 |
GABA(A) receptor-associated protein | NM_007278 | 3.78 | Up | 0.049 |
Gap junction protein, alpha 1, 43 kDa | NM_000165 | 4.91 | Up | 0.017 |
Glutathione peroxidase 1 | NM_000581 | 3.42 | Up | 0.036 |
Glutamate receptor, metabotropic 1 | U31216 | 1.06 | Up | 0.0082 |
Guanine nucleotide binding protein (G protein), gamma 10 | NM_004125 | 2.97 | Up | 0.049 |
Guanine nucleotide binding protein (G protein) alpha inhibiting activity polypeptide 3 | J03198 | 3.22 | Up | 0.021 |
Guanine nucleotide binding protein (G protein) beta polypeptide 1 | NM_002074 | 4.04 | Up | 0.015 |
Heat shock protein 90 kDa alpha (cytosolic), blass B member 1 | AF275719 | 2.96 | Up | 0.038 |
Hydroxysteroid (17-beta) dehydrogenase 4 | NM_000414 | 1.88 | Up | 0.049 |
Kv channel interacting protein 2 | AF367019 | 1.52 | Up | 0.027 |
Neurogenin 2 | AF022859 | 1.08 | up | 0.045 |
Neuron navigator 1 | N57538 | 2.42 | Up | 0.009 |
Neuron navigator 2 | AA011020 | 1.11 | Up | 0.043 |
Neuropilin 2 | AA295257 | 1.87 | Up | 0.037 |
Neuroplastin | NM_017455 | 2.78 | Up | 0.048 |
Opioid growth factor receptor | AF172449 | 1.31 | Up | 0.008 |
Palmitoyl-protein thioesterase 1 | NM_000310 | 3.04 | Up | 0.019 |
PDZ and LIM domain 5 | AV715767 | 5.1 | Up | 0.006 |
Peroxisome proliferator-activated receptor delta | NM_006238 | 3.31 | Down | 0.031 |
Phytanoyl-CoA 2-hydroxylase | NM_006214 | 2.17 | Up | 0.049 |
Potassium channel tetramerisation domain containing 10 | AS073741 | 2.69 | Up | 0.036 |
Potassium channel tetramerisation domain containing 15 | W73820 | 1.33 | Up | 0.013 |
Potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3 | NM_002252 | 1.66 | Up | 0.031 |
Presenilin 1 | NM_007318 | 1.61 | Up | 0.024 |
Regulator of G-protein signaling 5 | AF159570 | 2.31 | Up | 0.047 |
Reticulon 4 (Neurite growth inhibitor) | AF20999 | 4.61 | Up | 0.001 |
Solute carrier family 38, member 1 | NM_030674 | 2.13 | Up | 0.039 |
Solute carrier family 7 (catonic amino acid transporter, y + system), member 1 | AA148507 | 1.44 | Up | 0.017 |
Somatostatin receptor 4 | NM_001052 | 1.09 | Down | 0.033 |
S100 calcium binding protein A4 | NM_002961 | 7.44 | Up | 0.010 |
Thioredoxin domain containing 12 (endoplasmic reticulum) | AF131758 | 2/42 | Up | 0.009 |
Thy-1 cell surface antigen | AL161958 | 3.48 | Up | 0.006 |
B. Proinflammatory cytokine and chemokine genes: | ||||
Chemokine (C-X-C motif) receptor 7 | AI817041 | 3.32 | Up | 0.043 |
Chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1) | NM_000609 | 1.90 | Up | 0.024 |
FGF receptor 2 | T83672 | 1,12 | Up | 0.020 |
IL-17A | NM_002190 | 1.05 | Up | 0.048 |
Interferon induced transmembrane protein 1 (9–27) | NM_003641 | 2.72 | Up | 0.026 |
PDGF C | NM_016205 | 3.07 | Up | 0.041 |
PDGF alpha polypeptide | NM_006206 | 5.73 | Up | 0.021 |
PDGF receptor, beta polypeptide | NM_003609 | 2.10 | Up | 0.033 |
PDGF receptor-like | NM_006207 | 1.82 | Up | 0.037 |
TGF beta | NM_000358 | 6.68 | Up | 0.035 |
Latent TGF beta binding protein 1 | NM_000627 | 3.29 | Up | 0.016 |
TNF receptor-associated factor 5 | NM_004619 | 1.34 | Up | 0.014 |
VEGF B | NM_003377 | 1.09 | Up | 0.037 |
C. Genes with special disc relevance: | ||||
ADAM metallopeptidase domain 17 | NM_003183 | 1.56 | Up | 0.001 |
Apoptosis-inducing factor, mitochondrion associated, 1 | NM_004208 | 1.42 | Up | 0.019 |
BMP receptor, type II (serine/threonine kinase) | AI457436 | 1.51 | Up | 0.027 |
Calcitonin receptor-like | AI1478743 | 1.51 | Up | 0.035 |
Caspase 2, apoptosis-related cysteine peptidase | AU153405 | 1.63 | Up | 0.028 |
Caspase 6, apoptosis-related cysteine peptidase | BC000305 | 1.63 | Up | 0.048 |
Collagen, type I, alpha 1 | K01228 | 2.69 | Up | 0.046 |
Collagen, type I, alpha 2 | NM_000089 | 13.27 | Up | 0.007 |
Collagen type III, alpha 1 | AU144167 | 10.3 | Up | 0.036 |
Collagen type IV, alpha 2 | X05610 | 2.02 | Up | 0.021 |
Collagen type V, alpha 1 | AI9833428 | 1.5 | Up | 0.039 |
Collagen type VI, alpha 3 | NM_004369 | 5.85 | Up | 0.036 |
Connective tissue growth factor | M92934 | 6.47 | Up | 0.009 |
EGF-containing fibulin-like extracellular matrix protein 1 | NM_004105 | 1.49 | Up | 0.005 |
Fibronectin 1 | AK026737 | 16.82 | Up | 0.017 |
Fibronectin leucine rich transmembrane protein 2 | NM_013231 | 2.78 | Up | 0.023 |
Hypoxia inducible factor 1, alpha subunit | NM_001530 | 3.61 | Up | 0.037 |
Janus kinase 2 | AF001362 | 1.3 | Up | 0.002 |
Laminen, alpha 5 | BC003355 | 1.39 | Up | 0.042 |
Laminin, beta 1 | NM_002291 | 2.13 | Up | 0.045 |
Lumican | NM_002345 | 17.58 | Up | 0.015 |
Mitogen-activated protein kinase 1 | AF320999 | 4.61 | Up | 0.0017 |
Mitogen-activated protein kinase 13 | BC000433 | 1.37 | Up | 0.014 |
Mitogen-activated protein kinase kinase kinase 3 | BF971923 | 1.67 | Up | 0.045 |
Nitric oxide synthase 3 | NM_000603 | 4.77 | Down | 0.030 |
SPARC (osteonectin), cwcv and Kazal-like domains proteoglycan (testican) 1 | AF231124 | 2.74 | Up | 0.027 |
Thrombospondin 1 | BF055462 | 1.20 | Up | 0.033 |
TIMP metallopeptidase inhibitor 2 | BF107565 | 3.57 | Up | 0.034 |
TIMP metallopeptidase inhibitor 3 | U67195 | 2.88 | Up | 0.035 |
Vimentin | AI520969 | 1.35 | Up | 0.031 |