Table 4 Significant differences in pain-, neurotrophin-, nerve- and disc related gene expression in surgical compared to control (CHTN) specimens

A. Pain-, Neurotrophin-, and Nerve-related genes:

Adrenergic, beta, receptor kinase 1

Ataxin 1

Ataxin 10

Caireticulin

Calcitonin gene-related peptide

Calcium channel, voltage-dependent, gamma subunit 2 (stargazin)

Calcium channel, voltage-dependent, P/Q type, alpha 1A subunit

Calcium channel, voltage-dependent, beta 4 subunit

Calmodulin 3 (phosphorylase kinase, delta)

Calreticulin

Cannabinoid receptor 1 (brain)

Catechol-O-methyltransferase

Chloride intracellular channel 1

Cholinergic receptor, muscarinic 1

Ciliary neurotrophic factor

Clusterin

Early growth response 1

Family with sequence similarity 123, member B

Frizzled homolog 8

G protein-coupled receptor, family C, group 5, member C

G protein-coupled receptor 87

G protein-coupled receptor 98

G protein regulated inducer of neurite outgrowth 1

GABA binding protein 2

GABA(A) receptor-associated protein

GABA A receptor, beta 2

Gap junction protein, alpha 1, 43 kDa

Glutamate receptor, ionotropic, delta 2

Glutamate receptor, ionotropic, kainite 5

Glutamate receptor, ionotropic, N-methyl D-aspartate 2B

Glutamate receptor, metabotropic 5

Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3

Guanine nucleotide binding protein (G protein), beta polypeptide 1

Guanine nucleotide binding protein (G protein), alpha 11 (Gq class)

Glutathione peroxidase 1

Low density lipoprotein-related protein 1

Meteorin, glial cell differentiation regulator

Natriuretic peptide receptor B/guanylate cyclase B

Nerve growth factor, beta polypeptide

Netrin 1

Neugrin, neurite outgrowth associated

Neuroligin 1

Neuron navigator 1

Neuro-oncological ventral antigen 1

Neuropilin 2

Neuroplastin

Neurotensin

Nexin (serpin peptidase inhibitor, claude E)

Oligophrenin 1

Opioid growth factor receptor-like 1

Palmitoyl-protein thioesterase 1

PDZ and LIM domain 5

Potassium large conductance calcium-activated channel, subfamily M, alpha member 1

Potassium voltage-gated channel, shaker-related subfamily, member 10

Potassium channel tetramerisation domain containing 20

Prepronociceptin

Regulator of G-protein signaling 3

Regulator of G-protein signaling 12

Regulator of G-protein signaling 18

Reticulon 4 (Neurite growth inhibitor)

Roundabout, axon guidance receptor, homolog 3

S100 calcium binding protein A4

S100 calcium binding protein A6

S100 calcium binding protein B

Sigma non-opioid intracellular receptor 1

Solute carrier family 1 (glutamate/neutral amino acid transporter), member 4

Solute carrier family 29 (nucleoside transporters), member 1

Solute carrier family 38, member 1

Synaptopodin

Thioredoxin domain containing 5 (endoplasmic reticulum)

Thy-1 cell surface antigen

Voltage-dependent anion channel 2

Xylosyltransferase 1

B. Proinflammatory cytokine and chemokine genes:

Chemokine (C-X-C motif) ligand 2

Chemokine (C-X-C motif) receptor 7

FGF 1 (acidic)

FGF 5

FGF receptor substrate 2

FGF receptor 3

FGF receptor substrate 2

IL-1 receptor-associated kinase 1

IL-1 receptor-like 1

IL-31 receptor B1

IL-6 signal transducer (gp130, oncostatin M receptor)

Interferon gamma receptor 2

Macrophate migration inhibitory factor

PDGF C

PDGF receptor, alpha polypeptide

TGF beta

TGF beta receptor 1

TNF (ligand) superfamily, member 11

TNF alpha-indued protein 6

TNF receptor superfamily member 1A

TNF receptor superfamily, member 10c, decoy without an intracellular domain

TNF receptor superfamily, member 10d, decoy without an intracellular domain

TNF receptor superfamily, member 12A

TNF receptor superfamily, member 25

TNF receptor-associatee factor 3

C. Genes with special disc relevance:

ADAM metallopeptidase domain 17

ADAM metallopeptidase domain 22

BCL2-associated athanogene 5

BMP and activin membrane-bound inhibitor homolog

Brevican

Caspase 6, apoptosis-related cysteine peptidase

Collagen type II, alpha 1

EGF-containing fibulin-like extracellular matrix protein 2

FGF 5

Fibronectin 1

Growth arrest specific 1

Growth arrest specific 7

Heat shock 70kDa protein 5

Heat shock 70kDa protein 8

Heat shock protein 90 kDa beta, (group 94), member 1

Hypoxia inducible factor 1, alpha subunit

Laminin, beta 2

Latent TGF beta binding protein 1

Lumican

Lysyl oxidase-like 2

Mitogen-activated protein kinase 1

Mitogen-activated protein kinase 3

Mitogen-activated protein kinase kinase kinase 3

Mitogen-activated protein kinase 13

Mitogen-activated protein kinase 14

Proteoglycan 4

PTH 1 receptor

Retinoic acid receptor, beta

SOD

SPARC/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1

Tenascin R

Thyroid stimulating hormone receptor

TIMP metallopeptidase inhibitor 3

TIMP metallopeptidase inhibitor 4

Versican