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Table 4 Significant differences in pain-, neurotrophin-, nerve- and disc related gene expression in surgical compared to control (CHTN) specimens

From: Genome-wide analysis of pain-, nerve- and neurotrophin -related gene expression in the degenerating human annulus

Gene name Gene identifier Fold change Direction p-value
A. Pain-, Neurotrophin-, and Nerve-related genes:
Adrenergic, beta, receptor kinase 1 NM_001619 1.28 Down 0.015
Ataxin 1 NM_000332 1.89 Up 0.026
Ataxin 10 AF119662 2.43 Up 0.016
Caireticulin NM_004343 8.53 Up 0.005
Calcitonin gene-related peptide M26095 1.21 Down 0.005
Calcium channel, voltage-dependent, gamma subunit 2 (stargazin) NM_006078 1.18 Down 0.037
Calcium channel, voltage-dependent, P/Q type, alpha 1A subunit AA769818 1.92 Up 0.023
Calcium channel, voltage-dependent, beta 4 subunit NM_000726 1.24 Down 0.001
Calmodulin 3 (phosphorylase kinase, delta) NM_005184 4.29 Up 0.002
Calreticulin NM_004343 8.53 Up 0.005
Cannabinoid receptor 1 (brain) NM_001840 1.14 Down 0.021
Catechol-O-methyltransferase AW139431 1.29 Down 0.035
Chloride intracellular channel 1 L08666 3.61 Up 0.035
Cholinergic receptor, muscarinic 1 AI500293 1.99 Down 0.001
Ciliary neurotrophic factor NM_000614 1.14 Down 0.040
Clusterin AI982754 20.62 Up 0.008
Early growth response 1 NM_001964 5.73 Up 0.013
Family with sequence similarity 123, member B NM_019000 3.45 Up 0.022
Frizzled homolog 8 AB043703 2.81 Up 0.016
G protein-coupled receptor, family C, group 5, member C NM_022036 2.32 Up 0.039
G protein-coupled receptor 87 NM_023915 1.17 Down 0.006
G protein-coupled receptor 98 AF037334 1.17 Down 0.043
G protein regulated inducer of neurite outgrowth 1 AI052709 1.05 Down 0.046
GABA binding protein 2 BC002557 8.78 Down 0.0006
GABA(A) receptor-associated protein NM_007278 4.04 Up 0.038
GABA A receptor, beta 2 NM_021911 1.2 Down 0.006
Gap junction protein, alpha 1, 43 kDa NM_000165 4.1 Up 0.038
Glutamate receptor, ionotropic, delta 2 NM_001510 1.17 Down 0.046
Glutamate receptor, ionotropic, kainite 5 S40369 1.28 Down 0.009
Glutamate receptor, ionotropic, N-methyl D-aspartate 2B NM_024016 1.08 Down 0.017
Glutamate receptor, metabotropic 5 D60132 1.38 Down 0.007
Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 J03198 2.87 Up 0.040
Guanine nucleotide binding protein (G protein), beta polypeptide 1 NM_002074 4.36 Up 0.009
Guanine nucleotide binding protein (G protein), alpha 11 (Gq class) NM_002067 1.29 Up 0.024
Glutathione peroxidase 1 NM_000581 3.62 Up 0.028
Low density lipoprotein-related protein 1 NM_002332 5.26 Up 0.034
Meteorin, glial cell differentiation regulator BE965311 1.28 Down 0.049
Natriuretic peptide receptor B/guanylate cyclase B NM_003995 1.55 Up J0.033
Nerve growth factor, beta polypeptide NM_002506 1.44 Up 0.03
Netrin 1 BF591483 1.16 Down 0.041
Neugrin, neurite outgrowth associated AL037339 2.66 Up 0.028
Neuroligin 1 AI912122 1.13 Down 0.043
Neuron navigator 1 AB032977 3.83 Up 0.005
Neuro-oncological ventral antigen 1 NM_002515 3.1 Up 0.0008
Neuropilin 2 BC009222 3.28 Up 0.014
Neuroplastin NM_017455 3.61 Up 0.015
Neurotensin NM_006183 1.22 Down 0.009
Nexin (serpin peptidase inhibitor, claude E) AL541302 5.64 Up 0.009
Oligophrenin 1 NM_002547 2.82 Up 0.048
Opioid growth factor receptor-like 1 BE500942 2.4 Up 0.023
Palmitoyl-protein thioesterase 1 NM_000310 3.64 Up 0.005
PDZ and LIM domain 5 AV15767 5.06 Up 0.006
Potassium large conductance calcium-activated channel, subfamily M, alpha member 1 U11058 3.44 Up 0.040
Potassium voltage-gated channel, shaker-related subfamily, member 10 NM_005549 2.02 Down 0.010
Potassium channel tetramerisation domain containing 20 AV707142 2.34 Up 0.018
Prepronociceptin NM_006228 1.04 Down 0.027
Regulator of G-protein signaling 3 NM_021106 2.45 Up 0.039
Regulator of G-protein signaling 12 AF030111 1.18 Down 0.006
Regulator of G-protein signaling 18 AF076642 1.3 Down 0.025
Reticulon 4 (Neurite growth inhibitor) AB015639 5.96 Up 0.004
Roundabout, axon guidance receptor, homolog 3 NM_022370 1.89 Up 0.025
S100 calcium binding protein A4 NM_002961 12.85 Up 0.003
S100 calcium binding protein A6 NM_014624 6.97 Up 0.013
S100 calcium binding protein B BC001766 3.48 Up 0.009
Sigma non-opioid intracellular receptor 1 NM_005866 1.64 Up 0.031
Solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 W72527 4.06 Up 0.001
Solute carrier family 29 (nucleoside transporters), member 1 NM_004955 2.89 0.009  
Solute carrier family 38, member 1 NM_030674 2.39 Up 0.015
Synaptopodin NM_007286 2.24 Up 0.032
Thioredoxin domain containing 5 (endoplasmic reticulum) NM_030810 6.05 Up 0.002
Thy-1 cell surface antigen AL161958 3.13 Up 0.013
Voltage-dependent anion channel 2 L08666 3.61 Up 0.035
Xylosyltransferase 1 AI693140 6.23 Up 0.004
B. Proinflammatory cytokine and chemokine genes:
Chemokine (C-X-C motif) ligand 2 AV648479 1.15 Down 0.027
Chemokine (C-X-C motif) receptor 7 AI817041 4.13 Up 0.014
FGF 1 (acidic) X59065 2.17 Up 0.033
FGF 5 AB016517 1.47 Down 0.015
FGF receptor substrate 2 AI708648 1.23 Down 0.027
FGF receptor 3 NM_000142 2.62 Up 0.048
FGF receptor substrate 2 AI708648 1.23 Down 0.027
IL-1 receptor-associated kinase 1 NM_001569 3.98 Up 0.010
IL-1 receptor-like 1 NM_003856 1.16 Down 0.041
IL-31 receptor B1 NM_139017 1.17 Down 0.025
IL-6 signal transducer (gp130, oncostatin M receptor) AW242916 1.56 Down 0.032
Interferon gamma receptor 2 NM_005534 2.25 Up 0.041
Macrophate migration inhibitory factor NM_002415 5.71 Up 0.004
PDGF C NM_016205 4.62 Up 0.003
PDGF receptor, alpha polypeptide NM_006206 6.63 Up 0.011
TGF beta NM_000358 8.77 Up 0.014
TGF beta receptor 1 AA604375 3.14 Up 0.023
TNF (ligand) superfamily, member 11 AF053712 3.28 Up 0.009
TNF alpha-indued protein 6 AW188198 9.91 Up 0.006
TNF receptor superfamily member 1A NM_001065 2.01 Up 0.040
TNF receptor superfamily, member 10c, decoy without an intracellular domain AK026079 1.34 Down 0.014
TNF receptor superfamily, member 10d, decoy without an intracellular domain NM_003841 1.18 Down 0.039
TNF receptor superfamily, member 12A NM_016639 2.01 Up 0.046
TNF receptor superfamily, member 25 U94506 1.16 Down 0.012
TNF receptor-associatee factor 3 AI721219 1.57 Up 0.046
C. Genes with special disc relevance:
ADAM metallopeptidase domain 17 NM_003183 1.38 Up 0.025
ADAM metallopeptidase domain 22 NM_021723 1.18 Down 0.045
BCL2-associated athanogene 5 NM_004873 1.9 Up 0.028
BMP and activin membrane-bound inhibitor homolog NM_012342 3.28 Up 0.008
Brevican AA622130 1.30 Down 0.044
Caspase 6, apoptosis-related cysteine peptidase BC000305 2.05 Up <0.0001
Collagen type II, alpha 1 X)6268 53.83 Up 0.009
EGF-containing fibulin-like extracellular matrix protein 2 NM_005507 11.88 Up 0.012
FGF 5 AB016517 1.47 Down 0.015
Fibronectin 1 AK026737 37.09 Up 0.001
Growth arrest specific 1 NM_002048 5.44 Up 0.006
Growth arrest specific 7 BE439987 2.56 Up 0.040
Heat shock 70kDa protein 5 AW052044 1.34 Up 0.047
Heat shock 70kDa protein 8 AA704004 3.99 Up 0.023
Heat shock protein 90 kDa beta, (group 94), member 1 AK025862 2.45 Up 0.031
Hypoxia inducible factor 1, alpha subunit NM_001530 4.41 Up 0.014
Laminin, beta 2 X79683 3.24 Up 0.029
Latent TGF beta binding protein 1 NM_000627 3.09 Up 0.024
Lumican NM_002345 66.35 Up 0.0001
Lysyl oxidase-like 2 NM_002318 5.06 Up 0.010
Mitogen-activated protein kinase 1 BF434653 1.38 Down 0.018
Mitogen-activated protein kinase 3 X60188 1.94 Up 0.030
Mitogen-activated protein kinase kinase kinase 3 BF971923 1.83 Up 0.016
Mitogen-activated protein kinase 13 BC000433 1.35 Up 0.020
Mitogen-activated protein kinase 14 AA604375 3.14 Up 0.023
Proteoglycan 4 NM_005807 13.72 Up 0.001
PTH 1 receptor NM_000316 1.77 Up 0.047
Retinoic acid receptor, beta NM_000965 1.61 Up 0.036
SOD NM_000454 4.18 Up 0.023
SPARC/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 AF231124 3.00 Up 0.015
Tenascin R Y13359 1.38 Down 0.014
Thyroid stimulating hormone receptor BE045816 1.26 Down 0.019
TIMP metallopeptidase inhibitor 3 NM_000362 12.35 Up 0.001
TIMP metallopeptidase inhibitor 4 NM_003256 2.43 Up 0.042
Versican BF218922 5.19 Up 0.021