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Table 5 Significant differences in pain-, neurotrophin-, nerve-related and disc genes in herniated discs compared to control (CHTN) discs

From: Genome-wide analysis of pain-, nerve- and neurotrophin -related gene expression in the degenerating human annulus

Gene name Gene identifier Fold change Direction p-value
A. Pain-, Neurotrophin-, Nerve-related Genes:  
Adrenergic, beta, receptor kinase 1 NM-001619 1.33 Down 0.042
Ataxin 1 NM_000332 2.09 Up 0.031
Calcitonin gene related peptide M26095 1.2 Down 0.040
Calcium channel, voltage-dependent, P/Q type, alpha 1A subunit AA769818 2.17 Up 0.018
Calcium channel, voltage-dependent, beta 2 subunit U80764 1.21 Up 0.037
Cannabinoid receptor 1 (brain) NM-001840 1.16 Down 0.029
Chemokine (C-X-C motif) receptor 7 AI817041 4.51 Up 0.012
Cholinergic receptor, muscarinic 1 AI500293 2.05 Down 0.003
Clusterin M25915 20.02 Up 0.003
Corticotropin releasing hormone receptor 1 X72304 1.53 Up 0.035
EPH receptor B3 NM_004443 1.52 Up 0.037
Family with sequence similarity 134, member B NM_019000 3.72 Up 0.021
GABA(A) receptor-associated protein NM_007278 4.39 Up 0.039
GABA A receptor, beta 2 NM_021911 1.21 Down 0.016
G protein-coupled receptor, family C, group 5, member C NM_022036 2.64 Up 0.036
G protein-coupled receptor 52 NM_005684 1.06 Down 0.044
G protein-coupled receptor 161 AI703188 1.71 Up 0.044
G protein signaling modulator 2 (AGS3-like) AW195581 1.94 Up 0.040
Glutamate receptor, metabotropic 5 D60132 1.37 Down 0.026
Glutaminase NM_014905 3.14 Up 0.014
Glutathione peroxidase 1 NM_000581 3.94 Up 0.038
Guanine nucleotide binding protein (G protein), beta polypeptide 1 NM_002074 4.61 Up 0.013
Guanine nucleotide binding protein (G protein), gamma 5 NM_005274 2.62 Up 0.040
Guanine nucleotide binding protein (G protein), gamma 7 AL039870 1.54 Up 0.006
Guanine nucleotide binding protein (G protein), gamma 10 AI765321 1.49 Up 0.040
Guanine nucleotide binding protein (G protein), gamma 11 NM_004126 3.13 Up 0.026
Guanine nucleotide binding protein (G protein), gamma 12 N32508 1.86 Up 0.026
Guanine nucleotide binding protein (G protein), alpha 13 AI928136 2.80 Up 0.022
Kallidrein-related peptidase 8 NM_144506 1.21 Down 0.028
Monoglyceride lipase BG168471 1.79 Up 0.019
Myelin basic protein N37023 3.28 Up 0.003
Natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B) NM_003995 2.14 Up 0.049
Neogenin homolog 1 BF058828 1.28 Down 0.022
Nerve growth factor (beta polypeptide) NM_002506 1.5 Up 0.029
Neural precursor cell expressed, developmentally downregulated 4-like AB007899 1.23 Up 0.038
Neuromedin U receptor 2 AF272363 1.09 Down 0.023
Neuro-oncological ventral antigen 1 NM_002515 3.1 Up 0.001
Neurofibromin 1 M60915 1.04 Up 0.031
Neuromedin U receptor 2 AF272363 1.09 Down 0.023
Neuropilin 2 AA295257 3.92 Up 0.032
Neuroplastin NM_017455 4.46 Up 0.008
Opioid growth factor receptor-like 1 BE500942 2.52 Up 0.017
Palmitoyl-protein thioesterase 1 NM_000310 4.34 Up 0.005
Pancreatic polypeptide receptor 1 U42387 1.31 Down 0.048
PDZ and LIM domain 5 AV715767 5.04 Up 0.007
Plexin A1 T16388 1.51 Down 0.046
Potassium voltage-gated channel, shaker-related subfamily, member 10 NM_005549 2.36 Down 0.007
Prostaglandin E receptor 2 (subtype EP2), 53 kDa NM_000956 1.45 Up 0.048
Regulator of G-protein signaling 3 NM_021106 3.15 Up 0.021
Regulator of G-protein signaling 12 AF030111 1.18 Down 0.027
Regulator of G-protein signaling 14 NM_006480 1.13 Up 0.042
Reticulon 4 (neurite growth inhibitor) AB015639 5.58 Up 0.007
Roundabout, axon guidance receptor, homolog 3 NM_022370 1.74 Up 0.048
S100 calcium binding protein A6 NM_014624 9.13 Up 0.017
S100 calcium binding protein A9 NM_002965 1.93 Up 0.046
S100 calcium binding protein B BC001766 4.18 Up 0.012
Sigma non-opioid intracellular receptor NM_005866 2.01 Up 0.022
Solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 AI889380 2.79 Up 0.013
Solute carrier family 6 (neurotransmitter transporter, creatine), member 8 AI820043 1.65 Down 0.021
Solute carrier family 22, member 17 NM_020372 2.62 Up 0.044
Solute carrier family 29 (nucleoside transporters), member 1 NM_004955 4.03 Up 0.010
Solute carrier family 38, member 1 NM_030674 2.25 Up 0.023
Solute carrier family 38, member 2 NM_018976 2.24 Up 0.048
Solute carrier family 44, member 2 AI264216 1.88 Up 0.020
Syntaxin 1A (brain) NM_004603 2.46 Up 0.017
Syntaxin binding protein 1 NM_003165 1.96 Up 0.049
Thy-1 cell surface antigen NM_000633 2.24 Up 0.025
Xylosyltransferase I AI693140 6.41 Up 0.007
B. Proinflammatory cytokine and chemokine genes:     
Chemokine (C-C motif) ligand 22 NM_002990 1.10 Down 0.039
IL 11 receptor, alpha NM_147162 1.03 Down 0.049
IL 17 receptor C BF196320 1.11 Down 0.033
IL 27 receptor, alpha AI983115 1.19 Down 0.042
IL 31 receptor A AF106913 1.33 Down 0.040
IL-1 receptor-associated kinase 1 NM_001569 4.30 Up 0.015
IL-23, alpha subunit P19 AJ296370 1.62 Up 0.023
Interferon gamma receptor 2 NM_005534 2.79 Up 0.028
Latent TGF beta binding protein 1 NM_000627 2.61 Up 0.039
Macrophage migration inhibitory factor NM_002415 5.01 Up 0.034
PDGF receptor, alpha polypeptide NM_006206 5.96 Up 0.018
TGF beta NM_000358 12.34 Up 0.011
TGF beta receptor 1 NM_000714 3.88 Up 0.018
TNF alpha-induced protein 6 AW188198 14.57 Up 0.002
TNF receptor superfamily, member 11b NM_002546 3.31 Up 0.034
TNF receptor superfamily, member 12A NM_016639 2.29 Up 0.042
TNF receptor superfamily, member 25 U94506 1.13 Down 0.046
TNF receptor-associated factor 3 AI721219 1.67 Up 0.043
TNF superfamily, member 11 AF053712 4.32 Up 0.002
C. Genes with special relevance to the disc:  
ADAM metallopeptidase domain 17 NM_003183 1.36 Up 0.045
BCL2-associated athanogene 5 NM_004873 1.95 Up 0.039
Caspase 6, apoptosis-related cysteine peptidase BC000305 2.48 Up 0.025
Collagen type I, alpha 2 NM_000089 11.05 Up 0.017
Collagen type II, alpha 1 X06268 58.92 Up 0.0001
Collagen type III, alpha 1 AU144167 12.15 Up 0.026
Collagen type VI, alpha 2 AL531750 3.14 Up 0.018
Collagen type VI, alpha 3 NM_004369 8.55 Up 0.013
Collagen type VI, alpha 1 AA292373 3.12 Up 0.037
Collagen type XI, alpha 1 NM_001854 6.45 Up 0.020
Collagen type IX, alpha 3 NM_001853 10.38 Up 0.002
EGF receptor pathway substrate 8 NM_004447 1.55 Up 0.048
EGF-containing fibulin-like extracellular matrix protein 2 NM_005507 9.96 Up 0.037
Fibronectin 1 AK026737 52.43 Up 0.0004
Fibronectin leucine rich transmembrane protein 2 NM_013231 2.61 Up 0.028
Growth arrest-specific 1 NM_002048 5.45 Up 0.006
Growth arrest-specific 7 NM_005890 2.04 Up 0.045
Heat shock 70 kDa protein 8 AA704004 5.36 Up 0.008
Hypoxia indicuble factor 3, alpha subunit NM_001530 4.32 Up 0.027
Hypoxia inducible factor 1 (HIF1A) NM_001530 4.32 Up 0.027
Jun oncogene NM_002228 2.21 Up 0.027
Lumican NM_002345 79.38 Up <0.0001
Lysly oxidase-like 2 NM_002318 5.85 Up 0.009
Mitogen activated protein kinase 1 BF434653 1.44 Down 0.022
Mitogen-activated protein kinase 3 X60188 2.28 Up 0.023
Mitogen-activated protein kinase 8 AU152505 1.41 Up 0.048
Mitogen-activated protein kinase 13 BC000433 1.32 Up 0.030
Mitogen-activated protein kinase 14 NM_001315 4.30 Up 0.006
Never in mitosis gene a (NIMA)-related kinase 8 AI9365173 1.81 Up 0.006
Never in mitosis gene a (NIMA)-related kinase 7 AL080111 2.43 Up 0.039
Proteoglycan 4 NM_005807 18.05 Up 0.001
SOD 1, soluble NM_000454 4.44 Up 0.038
SPARC/osteonectin, cwcv and kazal-like domains proteoclycan (testican) 1 (SPOCK1) AF231124 3.3 Up 0.010
Thyrotropin-releasing hormone receptor D16845 1.25 Down 0.004
TIMP metallopeptidase inhibitor 2 BF107565 2.9 Up 0.046
TIMP metallopeptidase inhibitor 3 NM_000358 15.36 Up 0.002
Versican BF218922 6.59 Up 0.013
Vitamin D receptor AA454701 1.19 Down 0.039