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Figure 6 | Molecular Pain

Figure 6

From: Transforming growth factor beta induces sensory neuronal hyperexcitability, and contributes to pancreatic pain and hyperalgesia in rats with chronic pancreatitis

Figure 6

Effect of TGFβ neutralization on pancreatic nociception in naïve rats. Intraperitoneal injection of a neutralizing antibody to TGFβ1 (left panel) or a non-neutralizing antibody also directed against TGFβ1 (right panel) was administered as described in the text. Nocifensive behavior was measured in response to to electrical stimulation. The graphs show the pooled results of two replicate experiments, each of which showed a statistically significant result when analyzed independently. Baseline responses were obtained and then repeated one week after administration of the antibody. Treatment with the neutralizing antibody resulted in a enhancement of the behavioral response to electrical stimulation of the pancreas compared to baseline (P < 0.0001 for both stimulus and treatment; n = 8) whereas administration of the non-neutralizing antibody resulted in no changes in the response (n = 8).

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Molecular Pain

ISSN: 1744-8069

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