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Figure 5 | Molecular Pain

Figure 5

From: Expression of the transient receptor potential channels TRPV1, TRPA1 and TRPM8 in mouse trigeminal primary afferent neurons innervating the dura

Figure 5

The distribution of neurons expressing TRPV1 channels in the TG and dural afferent neuron populations. (A) Representative images of a TG section containing FG+ dural afferent neurons and neurons exhibiting TRPV1-ir. Arrowheads indicate neurons that are both FG+ and TRPV1+. (B) The percentage of TRPV1+ TG neurons in the V1/V2 and V3 divisions (n = 3 mice; on average, 730 V1/V2 neurons and 500 V3 neurons were counted from each mouse; *** p < 0.001, two-tailed t-test). (C) The percentages of V1/V2 TG neurons (the same data set as in B) and FG+ dural afferent neurons that are TRPV1+ (n = 3 mice, on average, 213 FG+ neurons were counted from each mouse; * p < 0.05, two-tailed t-test). (D) The size distribution of TRPV1+/FG+ dural afferent neurons (n = 151 neurons pooled from three mice) are similar to the TRPV1+ neurons in the V1/V2 divisions of the TG (n = 679 neurons pooled from three mice, p = 0.1, Mann–Whitney U test). (E) The sizes of TRPV1+ neurons (the same neurons as in D) are significantly smaller than those of the neurons in the V1/V2 divisions of the TG (n = 2189 neurons pooled from three mice, p < 0.001, Mann–Whitney U test). (F) The sizes of TRPV1+/FG+ dural afferents (the same neurons as in D) are significantly smaller than those of the total FG+ dural afferent neurons (n = 638 neurons pooled from three mice, p < 0.001, Mann–Whitney U test).

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